Reversal by ranolazine of doxorubicin-induced prolongation in the inactivation of late sodium current in rat dorsal root ganglion neurons.
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چکیده
منابع مشابه
Response to letter to the editor: Reversal by ranolazine of doxorubicin-induced prolongation in the inactivation of late sodium current in rat dorsal root ganglion neurons.
We were pleased to learn about the observations of Wu et al. [1] related to the effect of ranolazine on doxorubicin-induced changes in the late sodium current that occur in dorsal root ganglia. The results of their in vitro experiments using single unit recording techniques provide important evidence to support earlier observations that ranolazine’s modulation of the late sodium current plays a...
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Na(+) currents were recorded using patch-clamp techniques from small-diameter (<25 micrometers) dorsal root ganglion neurons, cultured from adult rats (>150 g). Late Na(+) currents maintained throughout long-duration voltage-clamp steps (>/=200 ms) were of two types: a low-threshold, tetrodotoxin-sensitive (TTX-s) current that was largely blocked by 200 nM TTX, and a high-threshold, TTX-resista...
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عنوان ژورنال:
- Pain medicine
دوره 16 5 شماره
صفحات -
تاریخ انتشار 2015